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Mitochondrial Dysfunction & Oxidative Stress
are ROOT CAUSES of Blinding Diseases
Vision has high ATP requirements
In the retina, ATP drives the visual cycle in the retinal pigment epithelium, photoreceptors, and neural retina. In the cornea, ATP powers endothelial cell pumps to keep the cornea clear.
constant ROS insult
Reactive oxygen species (ROS) are created in the retina by high oxygen tension in the choriocapillaris and in the cornea by constant exposure to UV light. ROS can also be created by external factors, like cataract surgery.
Nrf2 is a MASTER REGULATOR
of Mitochondrial Function
& Oxidative Stress
Increases mitochondrial function and detoxifies ROS which may be beneficial in a broad array of ophthalmic diseases.
Kuria has a PORTFOLIO
of patented Nrf2 activators
These activators increase expression of target protein in eye tissues, including retinal pigment epithelium, corneal endothelium, corneal stroma, corneal epithelium, lens epithelium, ciliary body, and trabecular meshwork.
Kuria will initiate 3 clinical programs, with 2 product candidates, within 12 months from funding.
View our CEO's company presentation for the 2023 Ophthalmology Futures Retina Forum (Amsterdam)
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